Heat Flow Modeling for Controlled Focusing of Microwave Hyperthermia of Breast Cancer: a Computational Feasibility Study

Jaswantsing L. Rajput, Anil B. Nandgaonkar, Sanjay L. Nalbalwar, Abhay E. Wagh

Abstract


Heating the tumor tissue with an optimized amount of microwave energy is a promising combinational therapy, called hyperthermia treatment (HT), used with chemotherapy and radiotherapy. This combinational therapy has shown improvement in the survivorship for patients, and life after treatment. In clinical practice, radiation oncologists are still not using HT as a standard therapy because of some side effects like toxicity and hotspots on the surrounding site. To address this issue, optimal focusing of microwave on tumors, with minimal damage of surrounding tissues, is essential to avoid the side effects of HT. Our article briefly discusses on optimal focusing of microwaves on a tumor, computational feasibility study, and analysis of hyperthermia treatment. For the achievement of best outcomes, electrostatic modeling and heat flow modeling of 2D female breast models with tumors have been carried out. The finite element method (FEM) is used to solve the bio-heat equation at the tumor domain, consisting of radiation and convection-based boundary conditions. Obtained simulation results show that the highest focusing of radiation power on and around the tumor inside the breast has been given higher efficiency for hyperthermia. Our 2D modeling simulation results are helpful for improving hyperthermia treatment of breast cancer patients, with minimal damage to cells in the surrounding. Also, the article includes a mathematical analysis of hyperthermia and FEM modeling results concerning temperature distribution, heat flow, electric field intensity, electric flux density, heat flux density, and temperature variations in the breast tumor.

Keywords


Breast cancer; heat flow modeling; hyperthermia treatment (HT); tissue; tumor.

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References


IARC Latest Global Cancer Data, Global Cancer Observatory, IARC, GLOBOCAN Sept-2, 2018. [Online] Available https://www.uicc.org/news/new-global-cancer-data-globocan-2018.

G. Fiorentini, D. Sarti, C. D. Gadaleta, M. Ballerini, C. Garfagno, T. Ranieri, and S. Guadagni, “A Narrative Review of Regional Hyperthermia: Updates From 2010 to 2019,” Integrative cancer therapies, vol. 19, pp. 1-13, 2020.

S. C. Bruningk, J. Ijaz, I. Rivens, S. Nill, G. T. Harr, and U. Oelfke, “A comprehensive model for heat-induced radio sensitization,” International Journal of Hyperthermia, vol. 34, pp. 392-402, 2018.

Hyperthermia of Breast Cancer: a Computational Feasibility Study N. G. Huilgol, S. Gupta, and C. R. Sridhar, “Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial,” Journal of Cancer Research and Therapeutics, vol. 6, pp. 492-496, 2010.

J. J. Bosque, G. F. Calvo, V. M. Pérez-García, and M. C. Navarro, “The interplay of blood flow and temperature in regional hyperthermia: a mathematical approach,” Royal Society Open Science, vol. 8: pp. 1-19, 2021.

D. Michael, R. Maximilian R, and Christine Allen, “Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy,” Advanced Drug Delivery Reviews, vol. 163–164, pp. 98-124, 2020.

C. P. César, H. RB. Orlande, M. J. Colaço, G. S. Dulikravich, Leonardo, A. B. Varón and B. D. Lamien, “Real-time temperature estimation with enhanced spatial resolution during MR-guided hyperthermia therapy,” Numerical Heat Transfer, Part A: Applications, vol. 8, pp. 782-806, 2020.

C. M. V. Leeuwen, A. L. Oei, R. T. Cate, N. A. P. Franken, A. Bel, L. J. A. Stalpers, J. Crezee, and H. P. Kok, “Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation,” International Journal of Hyperthermia, vol. 34:1, pp. 30-38, 2018.

D. A. M. Iero, T. Isernia, and L. Crocco, “Thermal and Microwave Constrained Focusing for Patient-Specific Breast Cancer Hyperthermia: A Robustness Assessment,” IEEE Antennas Propagation. Trans., vol. 62, pp. 814–821, 2014.

G. G. Bellizzi, D. A. M. Iero, L. Crocco and T. Isernia, “Three-Dimensional Field Intensity Shaping: The Scalar Case,” IEEE Antennas and Wireless Propagation Letters, vol. 17, no. 3, pp. 360-363, 2018.

P. Gas, Miaskowski, and Arkadiusz, “SAR optimization for multi-dipole antenna array with regard to local hyperthermia,”. Przeglad Elektrotechniczny, vol. 95, pp.17-20, 2019.

M. Lazebnik, et al., “A large-scale study of the ultrawideband microwave dielectric properties of normal, malignant, benign breast tissue obtained from cancer surgeries,” Physics in Medicine & Biology, vol. 52, no. 20, pp. 6093-6115, 2007.

L. Xu, and X. Wang, “A Novel Microwave Power Deposition Monitoring Method by Thermoacoustic Imaging,” Cross Strait Quad-Regional Radio Science and Wireless Technology Conference (CSQRWC), Xuzhou, 2018, pp. 1-3, 2018. [Online]. Available: https: //doi: 10.1109/CSQRWC.2018.8455474.

P. T. Nguyen, S. Crozier, and A. Abbosh, “Three-Dimensional Microwave Hyperthermia for Breast Cancer in a Realistic Environment Using Particle Swarm Optimization”, IEEE Transactions on Biomedical Engineering, vol. 64, no. 6, pp. 1335-1344, 2017.

P. T. Nguyen, A. Abbosh, and S. Crozier, “3-D Focused Microwave Hyperthermia for Breast Cancer Treatment with Experimental Validation,” IEEE Transactions on Antenna & Propagations. vol.65, no.7, pp.3489-3499, 2017.

H. F. G. Mendez, M. A. Polochè Arango, F. C. Rico, and I. E. D. Pardo, “Microwave Hyperthermia Study in Breast Cancer Treatment,” Congreso Internacional de Innovación y Tendencias en Ingenieria (CONIITI), Bogota, Colombia, 2019, pp. 1-5, 2019. [Online]. Available: https: //doi: 10.1109/CONIITI48476.2019.8960873.

Y. Chen, J. Yi, M. Selvaraj, Y. Hsiang, and K. Takahata, “Wireless Hyperthermia Stent System for Restenosis Treatment and Testing with Swine Model,” in IEEE Transactions on Biomedical Engineering, vol. 67, no. 4, pp. 2020.

J. L. Rajput, A. B. Nandgaonkar, S. L. Nalbalwar, and A. E. Wagh, “Design Study and Feasibility of Hyperthermia Technique,” in Computing in Engineering and Technology, Aurangabad, Maharashtra, India, Jan. 2019, vol. 1025, pp. 721-732, [Online]. Available: https: //doi.org/10.1007/978-981-32, 2020.

“Dielectric properties of body tissues,” https://itis.swiss/virtual population/tissue-properties/database/dielectric-properties, 2020.

H. H. Pennes, “Analysis of tissue and arterial blood temperatures in the resting human forearm,” Journal of Applied Physiology., vol. 85, pp. 5–34, 1948.




DOI: http://dx.doi.org/10.18517/ijaseit.11.4.14030

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