Protonated 14-membered 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradeca-7,14-diene Salts and Their Biological Activity
Abstract
The 14-membered heterocyclic 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradeca-7,14-diene, [(Me6[14]N4diene)], salts with structural formula of [(Me6[14]N4diene)]Br2(H2O)2), [(Me6[14]N4diene)Cl2])(H2O)3, Me6[14]N4diene.(ClO4)2, Me6[14]N4diene.(PF6)2¬  and  Me6[14]N4diene.(NO3)2  have been  synthesized without the necessity of a template. The salts were characterized by FTIR, and NMR spectroscopic techniques. X-ray study showed that the macrocyclic cation consists of a pair of protonated amines and azomethine nitrogen atoms located diagonally and opposite to each other. Only the macrocylic bromide and perchlorate salts showed activity against gram-positive E. faecalis and gram-negative E. Coli.
Keywords
Tetraaza; Curtis; Macrocylic; Metal Complexes; Biological Activity
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PDFDOI: http://dx.doi.org/10.18517/ijaseit.3.2.317
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Published by INSIGHT - Indonesian Society for Knowledge and Human Development