Characterization of the Urethane Based Tissue Equivalent Substitute for Phantom Construction: Model Molding, XCOM and MCNPX Studies

Olaseni M. Bello, Norehan M. Nor, Wan Muhamad S. Wan Hassan

Abstract


The Soft and Lung tissue equivalent substitute (STES and LTES) were developed from urethane PMC121/30 Dry (A and B) of Smooth-On, USA. The part A and B were mixed in the ratio 1:1 and further mixed with calcium carbonate (CaCO3) at a ratio 2:1 by mass. Air moisture was extracted from the mixture for 10minutes. This is the STES and the density after air extraction was 1.04gcm-3. The LTES was developed by mixing the STES and polystyrene beads at a ratio 10:1 by mass. The density of the LTES was 0.25gcm-3 after air extraction. The STES and the LTES were subjected to compression test for stress-strain analysis. The elemental composition of STES and LTES was achieved using XCOM software with the IUPAC nomenclatures of the source compounds as inputs. The elemental composition obtained was used to modify the lung and the soft tissue material of the AMALE and AFEMALE computational phantom of ORNL. The phantom was subjected to photon exposure (0.06MeV-15.00MeV) using MCNPX Version 27e. The results from MCNPX provided the bremsstrahlung, positron annihilation, and the fluorescence energies that was used to estimate the g-factor. The mass-energy transfer coefficient (μtra/ρ) and the mass-energy absorption coefficient (μen/ρ) were calculated using the values of g-factor, the fluence and the Kerma. The μen/ρ of the tissue-equivalent agrees with the National Institute of Standard values and the ICRU 44. The STES and LTES are technically proper research and teaching models for dose measurements with these results.

Keywords


Tissue equivalent; MCNPX; XCOM; LTES; STES; urethane; phantom.

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References


F. Paquet, M. R. Bailey, R. W. Leggett, and J. D. Harrison, “Assessment and interpretation of internal doses: uncertainty and variability,” ICRP 2015 Proceedngs, pp. 202–214, 2015. https://doi.org/10.1177/0146645316633595

M. A. Alsadig, A.A., Abbas, S., Kandaiya, S., Ashikin, N.A.R.N.N., Qaeed, “Differential dose absorptions for various biological tissue equivalent materials using Gafchromic XR-QA2 film in diagnostic radiology,” Appl. Radiat. Isot., vol. 129, pp. 130–134, 2017. https://doi.org/10.1016/j.apradiso.2017.08.021

P. Amini, I., Akhlaghi, P., Sarbakhsh, “Construction and verification of a physical chest phantom from suitable tissue-equivalent materials for computed tomography examinations,” Radiat. Phys. Chem., vol. 150, pp. 51–57, 2018. https://doi.org/10.1016/j.radphyschem.2018.04.020

S. Chan, K. Dittakan, and M. Garcia-constantino, “Image Texture Analysis for Medical Image Mining: A Comparative Study Direct to Osteoarthritis Classification using Knee X-ray Image,” Int. J. Adv. Sci. Eng. Inf. Technol., vol. 10, no. 6, pp. 2189–2199, 2020. https://doi.org/10.18517/ijaseit.10.6.8279

H. Tony and C. Apriono, “Design of THz High-Resistivity Silicon-Based Microstrip Antenna for Breast Cancer Imaging,” Int. J. Adv. Sci. Eng. Inf. Technol., vol. 10, no. 6, pp. 2640–2648, 2020. https://doi.org/10.18517/ijaseit.10.6.12887

A. A. Alshehri, T. Daws, and S. Ezekiel, “Medical Image Segmentation Using Multifractal Analysis,” Int. J. Adv. Sci. Eng. Inf. Technol., vol. 10, no. 2, pp. 420–429, 2020.

A. A. Bakri and Nik Noor Ashikin Nik Ab Razak, “Characterization of Low-Cost Materials as Human Tissue Equivalent Materials,” Asian J. Appl. Sci. (ISSN, vol. 07, no. 04, pp. 456–460, 2019.

C. K. Mcgarry et al., “Tissue Mimicking Materials for Imaging and Therapy Phantoms: Topical Review,” Phys. Med. Biol., vol. 65, no. 23TR01, 2020. https://doi.org/10.1088/1361-6560/abbd17

C. E. Ghezzi, B. Marelli, F. G. Omenetto, J. L. Funderburgh, and D. L. Kaplan, “3D Functional Corneal Stromal Tissue Equivalent Based on Corneal Stromal Stem Cells and Multi-Layered Silk Film Architecture,” PLoS One, vol. 12(1): e01, pp. 1–18, 2017. https://doi.org/10.1371/journal.pone.0169504

J. F. Winslow, D. E. Hyer, R. F. Fisher, C. J. Tien, and D. E. Hintenlang, “Construction of anthropomorphic phantoms for use in dosimetry studies,” J. Appl. Clin. Med. Phys., vol. 10, no. 3, pp. 195–204, 2009. https://doi.org/10.1120/jacmp.v10i3.2986

S. F. Monzari, G. Geraily, T. Hadisi Nia, H. Toolee, and M. Farzin, “Fabrication of anthropomorphic phantoms for use in total body irradiations studies,” J. Radiother. Pract., vol. 19, no. 3, pp. 242–247, 2020. https://doi.org/10.1017/s1460396919000591

H. Savoji, B. Godau, M. S. Hassani, and M. Akbari, “Skin Tissue Substitutes and Biomaterial Risk Assessment and Testing,” Front. Bioeng. Biotechnol., vol. 6, no. July, pp. 1–18, 2018. https://doi.org/10.3389/fbioe.2018.00086

A. K. Jones, D. E. Hintenlang, and W. E. Bolch, “Tissue-equivalent materials for construction of tomographic dosimetry phantoms in pediatric radiology,” Med. Phys., vol. 30, no. 8, pp. 2072–2081, Aug. 2003. https://doi.org/10.1118/1.1592641

S. Medeiros, O. Ramos, M. Bárbara, T. Berdeguez, L. V. De Sá, and S. Augusto, “Anthropomorphic phantoms-potential for more studies and training in radiology,” Int. J. Radiol. Radiat. Ther., vol. 2, no. 4, pp. 101–104, 2017. https://doi.org/10.15406/ijrrt.2017.02.00033

A. Mohammed Ali, A., Hogg, P., Johansen, S., England, “Construction and validation of a low-cost paediatric pelvis phantom,” Eur. J. Radiol., vol. 108, pp. 84–91, 2018. https://doi.org/10.1016/j.ejrad.2018.09.015

M. Monzari, S.F., Geraily, G., Hadisi Nia, T., Toolee, H., Farzin, “Fabrication of anthropomorphic phantoms for use in total body irradiations studies,” J. Radiother. Pract., vol. 19, no. (3), pp. 242–247, 2020. https://doi.org/10.1017/s1460396919000591

A. Rafiq, M. Abu, A. Faisal, D. Cahyani, and R. Sari, “An Easily Made, Low-Cost , Bone Equivalent Material Used in Phantom Construction of Computed Tomography,” Int. J. Appl. Eng. Res., vol. 13, no. 10, pp. 7604–7609, 2018.

J. A. Smith, A., Huang, M., Watkins, T., Baskin, J., Garlick, “De novo production of human extracellular matrix supports increased throughput and cellular complexity in 3D skin equivalent model,” J. Tissue Eng. Regen. Med., vol. 14, no. (8), pp. 1019–1027, 2020. https://doi.org/10.1002/term.3071

R. Zainon, N. A. B. Amin, and A. A. Tajuddin, “Establishment of paraffix wax compound and NaCl as soft-tissue equivalent material for phantom fabrication,” ASM Sci. J., vol. 12, no. Special Issue 3, 2019.

D. Shrotriya, R. S. Yadav, R. N. L. Srivastava, and T. R. Verma, “Design and development of an indigenous in-house tissue-equivalent female pelvic phantom for radiological dosimetric applications,” Iran. J. Med. Phys., vol. 15, no. 3, 2018. 10.22038/ijmp.2018.26717.1274

R. Ianniello, C., de Zwart, J.A., Duan, Q., Lattanzi, R., Brown, “Synthesized tissue-equivalent dielectric phantoms using salt and polyvinylpyrrolidone solutions,” Magn. Reson. Med., vol. 80, no. (1), pp. 413–419, 2018. https://doi.org/10.1002/mrm.27005

F. C. P. Ade, N., van Eeden, D., du Plessis, “Characterization of Nylon-12 as a water-equivalent solid phantom material for dosimetric measurements in therapeutic photon and electron beams,” Appl. Radiat. Isot., vol. 155, no. 108919, 2020. https://doi.org/10.1016/j.apradiso.2019.108919

N. Zoller et al., “Assessment of melanogenesis in a pigmented human tissue-cultured skin equivalent,” Indian J. Dermatol., vol. 64, no. 2, 2019. https://doi.org/10.4103/ijd.ijd_410_17

D. R. Gevaert, J., Chettle, “XRF analysis of strontium: Exploring cellulose as a soft tissue equivalent,” X-Ray Spectrom., vol. 48, no. (5), pp. 443–451, 2019. https://doi.org/10.1002/xrs.3025

F. A. Beaudoin Cloutier, C., Goyer, B., Perron, C., Gauvin, R., Auger, “In Vivo Evaluation and Imaging of a Bilayered Self-Assembled Skin Substitute Using a Decellularized Dermal Matrix Grafted on Mice,” Tissue Eng. - Part A, vol. 23, no. (7-8), pp. 313–322, 2017. https://doi.org/10.1089/ten.tea.2016.0296

S. Michael et al., “Tissue Engineered Skin Substitutes Created by Laser-Assisted Bioprinting Form Skin-Like Structures in the Dorsal Skin Fold Chamber in Mice,” PLoS One, vol. 8, no. 3, 2013. https://doi.org/10.1371/journal.pone.0057741

M. Alssabbagh, A. A. Tajuddin, M. A. Manap, and R. Zainon, “Fabrication of a thyroid phantom for image quality in nuclear medicine using the 3D printing technology,” ARPN J. Eng. Appl. Sci., vol. 12, no. 9, 2017.

Y.-N. Seol, Y., Kim, J., Kim, A., Choi, B.O., Kang, “Development of Tissue Equivalent Materials for a Multi-modality (CT&MRI) Phantom in MRI-guided Radiation Treatment,” J. Korean Phys. Soc., vol. 73, no. (7), pp. 1012–1018, 2018. https://doi.org/10.3938/jkps.73.1012

A. Haag, L.C., Jason, “Synthetic gelatins as soft tissue simulants,” AFTE J., vol. 52, no. (2), pp. 67–84, 2020.

J. L. Hirsch, S.D., Powers, J.M., Rhodes, “Neonatal Soft Tissue Reconstruction Using a Bioengineered Skin Substitute,” J. Craniofac. Surg., vol. 28, no. (2), pp. 489–491, 2017. https://doi.org/10.1097/scs.0000000000003346

S. Joshi, P. K. Ajikumar, K. Sivasubramanian, and V. Jayaraman, “Synthesis, characterization and low energy photon attenuation studies of bone tissue substitutes,” J. Polym. Eng., vol. 40, no. (2), pp. 99–108, 2020. https://doi.org/10.1515/polyeng-2019-0179

S. Prabhu, S. G. Bubbly, and S. B. Gudennavar, “Synthetic polymer hydrogels as potential tissue phantoms in radiation therapy and dosimetry,” Biomed. Phys. Eng. Express, vol. 6, no. (5), p. 05500, 2020. https://doi.org/10.1088/2057-1976/aba209

R. Singla, S. M. S. Abidi, A. I. Dar, and A. Acharya, “Nanomaterials as potential and versatile platform for next generation tissue engineering applications,” J. Biomed. Mater. Res. - Part B Appl. Biomater., vol. 107, no. 7, pp. 2433–2449, 2019. https://doi.org/10.1002/jbm.b.34327

V. P. Singh, N. M. Badiger, and H. R. Vega-Carrillo, “Neutron kerma factors and water equivalence of some tissue substitutes,” Appl. Radiat. Isot., vol. 103, 2015. https://doi.org/10.1016/j.apradiso.2015.05.014

B. C. Nascimento, A. Frimaio, R. M. M. Barrio, A. C. A. Sirico, and P. R. Costa, “Comparative analysis of the transmission properties of tissue equivalent materials,” Radiat. Phys. Chem., vol. 167, 2020. https://doi.org/10.1016/j.radphyschem.2019.04.050

R. Kargar Shaker Langaroodi, S. M. M. Abtahi, and M. E. Akbari, “Investigation of the radiological properties of various phantoms for their application in low energy X-rays dosimetry,” Radiat. Phys. Chem., vol. 157, 2019. https://doi.org/10.1016/j.radphyschem.2018.12.010

M. S. Saleh, H.H., Sharaf, J.M., Alkhateeb, S.B., Hamideen, “Studies on equivalent atomic number and photon build-up factors for some tissues and phantom materials.,” Radiat. Phys. Chem., vol. 165,108388, 2019. https://doi.org/10.1016/j.radphyschem.2019.108388

M. R. Hoerner, M. R. Maynard, D. A. Rajon, F. J. Bova, and D. E. Hintenlang, “Three-dimensional printing for construction of tissue-equivalent anthropomorphic phantoms and determination of conceptus dose,” in American Journal of Roentgenology, 2018, vol. 211, no. 6. https://doi.org/10.2214/ajr.17.19489

D. R. Dance, S. Christofides, A. D. A. Maidment, I. D. McLean, K. H. Ng, and T. Editors, Diagnostic Radiology Physics: A Handbook for Teachers and Students. 2014.

J. H. Hubbell and S. M. Seltzer, “NIST_ X-Ray Mass Attenuation Coefficients - Section 3 (Updated).” NIST, Gaithersburg, MD 20899, 2019.

F. Zhang et al., “Design and fabrication of a personalized anthropomorphic phantom using 3D printing and tissue equivalent materials,” Quant. Imaging Med. Surg., vol. 9, no. 6, pp. 94–100, 2019. https://doi.org/10.21037/qims.2018.08.01

S. Noblet, C., Delpon, G., Supiot, S., Paris, F., Chiavassa, “A new tissue segmentation method to calculate 3D dose in small animal radiation therapy,” Radiat. Oncol., vol. 13, no. (1), p. 32, 2018. https://doi.org/10.1186/s13014-018-0971-8

ICRP, “Conversion Coefficient for use in Radiological Protection against External Radiation: P74,” ICRP Publication 74, Ann. ICRP 26(3-4). ICRP, 1996https://doi.org/10.1016/s0146-6453(96)90003-2

M. R. Hoerner, M. R. Maynard, F. J. Bova, D. E. Hintenlang, R. Da, and B. Fj, “Three-Dimensional Printing for Construction of Tissue-Equivalent Anthropomorphic Phantoms and Determination of Conceptus Dose,” Med. Phys. Informatics, vol. 211, no. December, pp. 1283–1290, 2018. https://doi.org/10.2214/ajr.17.19489

E. Meyer-scott, C. Silberhorn, and A. Migdall, “Single-photon sources: Approaching the ideal through multiplexing Single-photon sources: Approaching the ideal through multiplexing,” Rev. Sci. Instrum., vol. 041101, no. April, 2020. https://doi.org/10.1063/5.0003320




DOI: http://dx.doi.org/10.18517/ijaseit.12.1.13815

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